Downtown Clayton Vacations from $381
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to $2,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Downtown Clayton Vacation
Your next great adventure beckons with a vacation package to Downtown Clayton. Fun, food and great times — you're sure to find it in this neighborhood. Kick start your trip to Downtown Clayton by heading to nearby attractions such as St. Louis Zoo, St. Louis Art Museum and Washington University in St. Louis. Whatever your ideal Downtown Clayton vacation may look like, you can turn it into reality with Expedia.
The Latest Downtown Clayton Vacation Packages
Price found within the past 48 hours. Click for updated prices.
The Cheshire
Price was $1,136, price is now $791 per person
$791
per person
Dec 25 - Jan 1
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,010 reviews)
A wonderful break from boring hotels! My kids loved all the artwork and the scavenger hunt. The pub food and drinks were fantastic, as was the hotel breakfast each morning. We will definitely plan to return.
Reviewed on Nov 9, 2026
Remodeled and Inviting Free EV
Price was $921, price is now $677 per person
$677
per person
Jan 28 - Jan 31
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
9.4/10 Exceptional! (3 reviews)
We had a great time with my family ❤️ thank you
Reviewed on Oct 12, 2026
Where to stay in Downtown Clayton
Find the best Downtown Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Downtown Clayton
Downtown St. Louis
4 out of top 10 points of interest in this area
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Downtown Clayton Hotel Deals
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $122 total per night from Dec 6 to Dec 7
$122 total
Dec 6 - Dec 7
Total with taxes and fees
8.8/10 Excellent! (3,530 reviews)
"The staff were very kind and welcoming! We enjoyed our stay. The rooms were very clean and comfortable. It also has a lovely breakfast. My favorite part about my stay was definitely the entire staff though I can’t say enough how wonderful everyone was."
Reviewed on Nov 9, 2026
Le Méridien St. Louis Clayton
7730 Bonhomme Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $179 total per night from Nov 22 to Nov 23
$179 total
Nov 22 - Nov 23
Total with taxes and fees
AC Hotel St. Louis Clayton
227 South Central Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$128 nightly
The price is $150 total per night from Nov 15 to Nov 16
$150 total
Nov 15 - Nov 16
Total with taxes and fees
9.2/10 Wonderful! (426 reviews)
"Nice place very clean, shower pressure was kind of weak"
Reviewed on Nov 7, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Things to do
StL's Signature "Sights and Bites" - Private Tour in St. Louis
$175
per adult
St. Louis Ghost Tour: Sinister Sins & Shadows
$24
per adult
100% of travellers recommend
St. Louis: Lemp Haunted Neighborhood Ghost Tour
$27
per adult
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.